Can Methotrexate Be Used for Abortion?

Nov 11, 2024

If you’re facing an unplanned pregnancy, you’ve likely already googled countless ways to terminate it privately. You may have discovered the drug Methotrexate and want to reach out to an abortion provider to discuss it.

We get it—unplanned pregnancy can be scary. But, it’s important to get all the facts so you can make a fully informed decision. In today’s blog, we’re exploring everything you need to know about Methotrexate abortion.

What is Methotrexate Used For?

Methotrexate is a drug that prevents the replication or growth of living cells. It can be used to treat several different conditions, including[1]:

  • Certain cancers
  • Rheumatoid arthritis
  • Crohn’s disease
  • Severe psoriasis
  • Ectopic pregnancy[2]

Abortion providers also prescribe methotrexate for pregnancy termination. However, the FDA has not officially approved the drug for abortion, making it off-label for this use.

How Does Methotrexate Work for Ectopic Pregnancy? 

An ectopic pregnancy refers to a pregnancy that has developed outside of the uterus and cannot proceed normally. If untreated, an ectopic pregnancy could cause death. 

After a thorough evaluation with blood work and an ultrasound, physicians often prescribe Methotrexate to a woman with a confirmed or suspected ectopic pregnancy. The Methotrexate stops the pregnancy from continuing.[3] Frequent follow-up with blood tests is required. 

How Does a Methotrexate Abortion Work? 

Methotrexate works by slowing the growth of cells.[4] In a Methotrexate abortion, the drug is administered to stop the pregnancy cells from growing. Misoprostol is taken afterward to expel the fetus from the uterus. 

What are the Side Effects of a Methotrexate Abortion? 

Possible side effects of Methotrexate include[5]:

  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness

What are the Risks of a Methotrexate Abortion? 

Even small doses of Methotrexate can pose risks. Because Methotrexate can affect the growth of healthy cells, it can impact many different organs and could cause reactions that include[6]:

  • Birth defects (if the abortion fails and the pregnancy is carried to term)
  • Heavy bleeding
  • Painful abdominal cramping (caused by the Misoprostol that is taken in combination with Methotrexate)[7]
  • Fertility impairment (caused by the Methotrexate abortion injection)[8]
  • Menstrual dysfunction[9]

Have Questions About Methotrexate Abortion? Get Answers at Mid Cities Women's Clinic.

At Mid Cities Women's Clinic we want to empower you with information about all of your options. Before choosing a Methotrexate abortion, call us today at 817-577-4387 to speak with our compassionate and qualified staff about your pregnancy options. 

Schedule Your Appointment

Please be aware that Mid Cities Women's Clinic does not provide or refer for abortion services. 

Sources

  1. U.S. National Library of Medicine. (2017, April 15). Methotrexate. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682019.html#
  2. Ectopic Pregnancy. Mayo Clinic. (2022, May 12). https://www.mayoclinic.org/diseases-conditions/ectopic-pregnancy/diagnosis-treatment/drc-20372093
  3. See source #2.
  4. See source #2.
  5. West-Ward, Pharmaceuticals Corporation, & FDA. (2020, August). Methotrexate Label. FDA. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/040054s015,s016,s017.pdf
  6. See source #5.
  7. U.S. National Library of Medicine. (2023, December 15). Mifepristone (Mifeprex). MedlinePlus. https://medlineplus.gov/druginfo/meds/a600042.html
  8. METHOTREXATE TABLETS, USP. FDA. (n.d.). https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/008085s066lbl.pdf 
  9. See source #8.
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